Mangesh Thorat trained as a surgical oncologist with special interest in breast cancer at Tata Memorial Hospital, India. After spending 2 years of breast cancer biomarker research at Indiana University, USA, he joined the Centre for Cancer Prevention at the Wolfson Institute of Preventive Medicine, London in 2009. Mangesh was awarded PhD by the University of London in January 2016 for his DCIS biomarker work. His research covers 3 broad areas interlinked with each other – cancer prevention, biomarkers and clinical trials. His cancer epidemiology and prevention research focuses on drug repurposing, particularly the role of aspirin in cancer prevention further leading to clinical trials of therapeutic cancer prevention agents. His biomarker research is focussed on biomarkers of early detection, and prognostication of pre-cancerous lesions to facilitate optimal implementation of preventive therapy. On clinical side, oncoplastic breast surgery remains his clinical focus.